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. Author manuscript; available in PMC: 2017 May 1.
Published in final edited form as: J Cell Physiol. 2015 Oct 19;231(5):1130–1141. doi: 10.1002/jcp.25210

Fig. 9. Schema showing the possible signal transduction pathways involved in Ang-II induced CF proliferation and migration.

Fig. 9

Double arrow denotes AT1/Nox4 physical association. Arrowheads denote interventions used in delineating the signaling pathway. Arrows in blue show amplification in IL-18’s pro-mitogenic and pro-migratory effects in cardiac fibroblasts. The Nox1/Nox4 dual inhibitor GKT137831 attenuates not only AT1/Nox4 interaction, but also Ang-II-induced proinflammatory, pro-mitogenic and pro-migratory effects.