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. Author manuscript; available in PMC: 2017 Feb 1.
Published in final edited form as: J Neurol Neurosurg Psychiatry. 2016 Nov 29;88(2):152–164. doi: 10.1136/jnnp-2016-314411

Figure 4.

Figure 4

(A) MAPT-locus on chromosome 17. The two SNPs, rs1358071 and rs199528, are shared between FTD and PD. Either SNP is in LD with rs1052553 whose major allele (A) tags the H1 MAPT-haplotype. The major alleles of rs1358071 and rs199528 are also the effect alleles, and they are in LD with rs1052553 (r2=0.75 and 0.84, respectively). Thus, the effect at this locus is H1 driven. (B) APOE locus. The two haplotypes a and b are depicted. Haplotype a is the one driven by rs6857 with 13 SNPs in LD (r2~0.8; font color: blue). Haplotype b is the one driven by rs405509 with 10 SNPs in LD (r2~0.8; font color: black). Rs6857 and rs405509, and the respective haplotypes a and b, are in LE (r2~0.1). FTD, frontotemporal dementia; LD, linkage disequilibrium; LE, linkage equilibrium; PD, Parkinson’s disease.