Table 3.
Novel SNPs showing association with FTD at conditional FDR<0.05
| SNP | Position | Chr | Nearest gene | Reference allele |
Associated phenotype |
Min Cond FDR |
IFGC phase I p-value |
IFGC phase I OR (95% CI) |
IFGC phase II p-value |
IFGC phase II OR (95% CI) |
Meta-analysis p-value |
Meta-analysis OR (95% CI) |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| rs4417745 | 241 225 364 | 2 | Intergenic; OTOS | A | PD | 2.73E-02 | 2.52E-05 | 1.36 (1.18-1.57) | 0.47 | 1.06 (0.90-1.25) | 3.20E-04 | 1.22 (1.09-1.36) |
| rs7664889 | 77 087 704 | 4 | Intronic; SCARB2 | T | PD | 3.23E-02 | 1.75E-04 | 0.73 (0.62-0.86) | 0.82 | 0.98 (0.81-1.18) | 3.18E-03 | 0.83 (0.73-0.94) |
| rs676768 | 116 030 773 | 10 | Intronic; VWA2# | T | PD | 4.25E-02 | 3.12E-04 | 0.78 (0.68-0.90) | 0.55 | 0.96 (0.82-1.11) | 2.40E-03 | 0.86 (0.78-0.95) |
| rs1328032 | 71 420 424 | 13 | Intergenic; DACH1 | A | AD | 1.38E-02 | 1.93E-07 | 0.67 (0.57-0.78) | 0.34 | 0.94 (0.83-1.06) | 7.39E-05 | 0.80 (0.72-0.88) |
| rs2446406 | 51 679 783 | 15 | Intronic; GLDN# | A | PD | 2.59E-02 | 7.18E-07 | 0.81 (0.74-0.88) | 0.40 | 0.96 (0.87-1.06) | 2.24E-05 | 0.87 (0.82-0.93) |
| rs7184882 | 73 737 373 | 16 | In orf; LOC101927998 |
T | AD | 4.24E-02 | 6.64E-07 | 0.71 (0.62-0.81) | 0.08 | 0.89 (0.78-1.02) | 3.08E-06 | 0.78 (0.71-0.86) |
| rs199528 | 44 843 136 | 17 | Intronic; WNT3 | T | PD | 1.79E-02 | 4.09E-05 | 0.82 (0.74-0.90) | 0.03 | 0.89 (0.80-0.99) | 9.59E-06 | 0.85 (0.79-0.91) |
| rs1358071 | 43 803 189 | 17 | Intronic; CRHR1 | A | PD | 2.01 E-02 | 4.96E-05 | 1.22 (1.12-1.31) | 0.001 | 1.16 (1.07-1.26) | 4.91 E-07 | 1.19 (1.11-1.27) |
| rs12964543 | 56 543 095 | 18 | Intronic; ZNF532# | A | PD | 2.71 E-02 | 1.12E-04 | 1.24 (1.11-1.38) | 0.24 | 1.05 (0.96-1.15) | 9.10E-04 | 1.12 (1.05-1.2) |
| rs6857 | 45 392 254 | 19 | 3′-UTR; PVRL2# | T | PD | 4.69E-02 | 7.03E-07 | 1.31 (1.18-1.46) | 4.46E-07 | 1.37 (1.21-1.55) | 2.21E-12 | 1.34 (1.23-1.45) |
| rs405509 | 45 408 836 | 19 | Intergenic; APOE | T | AD | 5.26E-03 | 1.25E-05 | 1.18 (1.09-1.27) | 0.93 | 1.0 (0.92-1.09) | 5.98E-05 | 1.15 (1.08-1.24) |
ORs provided for the reference allele.
#
rs676768 not available, proxy SNP rs12782946 from IFGC phase II.
#
rs2446406 not available, proxy SNP rs2445742 from IFGC phase II.
#
rs12964543 not available, proxy SNP exm2272683 from IFGC phase II.
#
rs6857 not available, proxy SNP rs2075650 from IFGC phase II.
AD, Alzheimer's disease; FDR, false discovery rate; FTD, frontotemporal dementia; IFGC, International FTD-Genomics Consortium; PD, Parkinson's disease.