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. Author manuscript; available in PMC: 2018 Feb 1.
Published in final edited form as: Kidney Int. 2016 Dec 15;91(2):501–511. doi: 10.1016/j.kint.2016.09.044

Figure 6. Glomerular ECM protein interaction network.

Figure 6

Analysis of identified proteomes using network analysis tools can provide valuable information for disease mechanisms. To demonstrate the robust LCMS data set collection using the limited amounts of glomerular ECM material, a schematic overview of the protein-protein interaction network established by modeling the glomerular ECM proteomes using The Search Tool for the Retrieval of Interacting Genes (STRING v10) database with the highest confidence score (0.900). 6a. STRING (v10) ECM protein-protein interaction network model (this study) identified seven clusters of interacting proteins including basement membrane and structural ECM proteins composed of 13 collagens, 6 laminins, and 8 heparan sulfate proteoglycan GBM proteins. 6b. STRING (v10) ECM protein-protein interaction network model (this and Lennon’s study) combined revealed two new networks containing one with matrix metalloproteinase 9 as the central node and a second with cathepsin’s –G and –Z as integral network components.