Table 3. Comparison of the Frequencies of Different Epithelial Changes in Bile Ducts of the Patients with PSC in Different Studies.
| Author | Year | Country | Specimen | No. of cases | Disease | Metaplasia, % | Dysplasia, % | ||
|---|---|---|---|---|---|---|---|---|---|
| BilIN 1 | BilIN 2 | BilIN 3 | |||||||
| Lewis et al. ( 4 ) | 2010 | USA | Explanted liver | 30 | PSC | 83 | |||
| Mucinous, 4 | |||||||||
| Pyloric, 73 | |||||||||
| Intestinal, 26 | |||||||||
| Pancreatic, 10 | |||||||||
| Wu et al. ( 19 ) | 2009 | USA | Explanted liver | 244 | NR | ||||
| Noncirrhotic | 40 | 16 | 0 | ||||||
| EtOH | 35 | 57 | 4 | ||||||
| EtOH + HCV | 38 | 54 | 4 | ||||||
| HCV | 55 | 20 | 7 | ||||||
| Sato et al. ( 20 ) | 2013 | Japan | Resected liver | 64 | PSC | NR | 30 | 7 | 0 |
| Fleming et al. ( 10 ) | 2001 | UK | Liver Bx | 60 | PSC | NR | 0 | ||
| Bergquist et al. ( 7 ) | 1998 | Sweden | Explanted liver | 20 | CCA | NR | 60 | ||
| Ludwig et al. ( 17 ) | 1992 | USA | Explanted liver | 60 | PSC | NR | 1.25 | ||
| Current Study | 2015 | Iran | Explanted liver | 80 | PSC | 0 | |||
| Pyloric 35 | |||||||||
| Mucinous 10.8 | |||||||||
| Intestinal 3.6 | |||||||||
| Osteoid 1.2 | |||||||||
| Squamous 1.2 | |||||||||
Abbreviations: CCA, cholangiocarcinoma; EtOH, alcohol-induced cirrhosis; HCV, hepatitis C virus; NR, Not reported; PSC, primary sclerosing cholangitis.