Table 4.
Univariate analysis of various potential prognostic factors for OS in patients with SPLAC
| Variable | Patients (n) |
Median OS (months) |
P-value |
|---|---|---|---|
| Gender | 0.628 | ||
| Male | 55 | 91.0±15.3 | |
| Female | 60 | 81.0±11.7 | |
| Age (years) | 0.679 | ||
| ≤60 | 61 | 81.0±16.2 | |
| >60 | 54 | 96.0±31.2 | |
| Smoking history | 0.824 | ||
| Never | 80 | 81.0±12.7 | |
| Ever | 35 | 91.0±13.5 | |
| Interval (months) | 0.888 | ||
| ≤24 | 63 | 96.0±33.7 | |
| >24 | 52 | 81.0±12.6 | |
| ECOG PS | 0.054 | ||
| 0–1 | 80 | 91.0±17.7 | |
| 2 | 35 | 66.0±11.0 | |
| Type of the first resection | 0.072 | ||
| Sublobar resection | 58 | 81.0±12.9 | |
| Lobar resection | 57 | 91.0±18.6 | |
| Type of the second resection | 0.206 | ||
| Sublobar resection | 57 | 81.0±15.5 | |
| Lobar resection | 58 | 91.0±17.7 | |
| TNM stage of the primary tumor | <0.001a | ||
| Stage I | 101.0±5.8 | ||
| Stage II | 48.0±7.1 | ||
| CT morphology of SPLAC | 0.001a | ||
| GGO-p | 73 | –b | |
| Solid-p | 42 | 59.0±8.0 | |
| Location | 0.308 | ||
| Ipsilateral | 39 | 67.0±27.5 | |
| Contralateral | 76 | 81.0 | |
| Histologic classification | 0.001a | ||
| Similar/same | 93 | 96.0±6.3 | |
| Different | 22 | 48.0±7.2 | |
| TNM stage of SPLAC | <0.001a | ||
| I | 83 | –b | |
| II | 19 | 66.0±11.2 | |
| IIIa | 13 | 32.0±7.6 | |
| Histologic grade of SPLAC | 0.001a | ||
| Low | 25 | 101.0 | |
| Intermediate | 72 | 91.0±15.7 | |
| High | 18 | 51.0±11.0 |
Notes:
a
Statistically significant.
b
Median survival unable to be estimated. Data presented as mean ± standard deviation. –, Not applicable, as more than half the number of patients were still alive.
Abbreviations: CT, computed tomography; ECOG, Eastern Cooperative Oncology Group; GGO-p, ground glass opacity predominant; MPLC, multiple primary lung cancer; OS, overall survival; PS, performance status; Solid-p, solid predominant; SPLAC, second primary lung adenocarcinoma; TNM, tumor, node, and metastasis.