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. 2017 Jan 16;7:670. doi: 10.3389/fimmu.2016.00670

Figure 1.

Figure 1

Mir146a−/− mice exhibit an increase in total splenic B-cells and immature splenic subsets, except exhibit a defect in marginal zone (MZ) B-cells. Cell numbers of (A) total live cells (*p = 0.015, ****p < 0.0001) and (B) B220+ B-cells (*p = 0.021, ****p < 0.0001) are shown in young mice, ages 8 weeks (n = 8–9 mice/group) and 12 weeks (n = 12–14 mice/group). Values are mean ± SD. (C) Representative FACS plots show maturing B-cell subsets in spleens of wild-type (WT) mice and Mir146a−/− knockout (KO) mice at 12 weeks. (D) Analysis of spleen subsets from WT mice and KO mice are shown at early ages (n = 12–14/group). Increases in the transitional T1 (***p = 0.0001) and T2 (*p = 0.043, ***p = 0.0003) B cells are shown. MZ B-cells are decreased in KO at ages 8 weeks (**p = 0.008), 12 weeks (****p < 0.0001). Values are mean ± SD.