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. 2017 Jan 16;7:670. doi: 10.3389/fimmu.2016.00670

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Copyright © 2017 King, Ung, Paing, Contreras, Alberti, Fernando, Zhang, Pellegrini and Rao.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Mir146a^−/− mice show intact bone marrow B-cell development. Cell numbers of (A) total live cells (p = nss) and (B) B220+ B-cells (p = nss) are shown in young mice, ages 8 weeks (n = 8 mice/group) and 12 weeks (n = 12–14 mice/group), respectively. Values are mean ± SD. (C) Representative FACS plots show bone marrow B progenitors cells (Hardy Fractions) in bone marrow of WT (top panel) and KO mice (bottom panel) at 12 weeks. (D) Analysis of B progenitor cell subsets from WT and KO mice at early ages (8 and 12 weeks). Fraction A (*p = 0.006), fraction F at 8 weeks (*p = 0.025) and 12 weeks (*p = 0.001). Values are mean ± SD.