Table 2.
Association of monocyte cytokine responses with susceptibility to TB recurrence. Cytokine expression in monocytes from the cases, prior to TB acquisition and controls over time were analyzed using the Generalized Estimating Equations (GEE) model correcting for repeated measures and matched variables.
| Cytokine | No TB recurrence | TB recurrence | Unadjusted Odds Ratio (95%CI) | p-value | ||
|---|---|---|---|---|---|---|
| N | Median (IQR) | N | Median (IQR) | |||
| Monocytes (CD14) | ||||||
| Antigen: BCG | ||||||
| IL-1β | 37 | 0.96 (0.00 – 2.86) | 12 | 1.46 (0.20 – 7.51) | 1.30 (1.09 – 1.55) | 0.0033 |
| IL-12 | 36 | 0.01 (0.00 – 0.51) | 9 | 0.08 (0.00 – 0.34) | 0.40 (0.01 – 11.15) | 0.5901 |
| IP10 | 36 | 0.13 (0.00 – 1.14) | 9 | 0.00 (0.00 – 1.34) | 1.53 (0.84 – 2.77) | 0.1640 |
| TNF-α | 36 | 1.19 (0.00 – 3.78) | 9 | 1.43 (0.38 – 5.41) | 1.06 (0.78 – 1.44) | 0.7162 |
| Antigen: LPS | ||||||
| IL-1β | 34 | 21.03 (0.00 – 45.51) | 11 | 0.92 (0.00 – 9.28) | 0.94 (0.89 – 1.00) | 0.0462 |
| IL-12 | 33 | 1.85 (0.00 – 7.28) | 9 | 3.08 (1.31 – 7.69) | 0.98 (0.85 – 1.13) | 0.8143 |
| IP10 | 33 | 0.00 (0.00 – 1.15) | 9 | 0.18 (0.00 – 2.86) | 0.94 (0.84 – 1.05) | 0.2807 |
| TNF-α | 33 | 57.44 (23.10 – 73.02) | 9 | 41.80 (20.95 – 61.51) | 0.95 (0.91 – 1.00) | 0.0316 |
| Antigen: HKLM | ||||||
| IL-1β | 38 | 45.45 (23.93 – 70.23) | 11 | 25.11 (4.44 – 52.85) | 0.96 (0.92 – 1.00) | 0.0564 |
| IL-12 | 37 | 4.81 (0.00 – 8.60) | 9 | 7.14 (4.51 – 7.75) | 1.07 (0.96 – 1.18) | 0.2294 |
| IP10 | 37 | 0.52 (0.00 – 1.92) | 9 | 2.13 (0.44 – 2.70) | 0.95 (0.86 – 1.04) | 0.2768 |
| TNF-α | 37 | 62.30 (28.50 – 74.55) | 9 | 59.60 (43.94 – 71.30) | 1.00 (0.95 – 1.05) | 0.9469 |
| Antigen: CL075 | ||||||
| IL-1β | 36 | 51.16 (32.04 – 73.55) | 11 | 10.05 (1.25 – 62.00) | 0.95 (0.91 – 0.99) | 0.0243 |
| IL-12 | 35 | 6.42 (2.02 – 15.30) | 9 | 11.29 (9.76 – 18.65) | 1.02 (0.96 – 1.08) | 0.5811 |
| IP10 | 35 | 0.09 (0.00 – 1.88) | 9 | 0.54 (0.00 – 1.54) | 1.61 (0.80 – 3.24) | 0.1815 |
| TNF-α | 35 | 62.88 (46.20 – 76.72) | 9 | 62.71 (24.45 – 77.10) | 0.99 (0.94 – 1.03) | 0.4948 |
| Antigen: LAMMS | ||||||
| IL-1β | 16 | 34.81 (28.60 – 56.89) | 5 | 12.50 (0.00 – 17.21) | N/A | |
| IL-12 | 15 | 1.19 (0.33 – 1.42) | 2 | 1.40 (0.95 – 1.85) | N/A | |
| IP10 | 15 | 0.00 (0.00 – 0.75) | 2 | 0.08 (0.00 – 0.16) | N/A | |
| TNF-α | 15 | 40.83 (28.90 – 52.18) | 2 | 43.49 (34.22 – 52.75) | N/A | |
| Antigen: TDB | ||||||
| IL-1β | 12 | 19.05 (8.97 – 33.42) | 5 | 0.00 (0.00 – 6.33) | N/A | |
| IL-12 | 11 | 4.61 (1.96 – 8.65) | 2 | 11.04 (9.17 – 12.90) | N/A | |
| IP10 | 11 | 0.00 (0.00 – 0.83) | 2 | 0.21 (0.00 – 0.42) | N/A | |
| TNF-α | 11 | 71.22 (52.90 – 76.01) | 2 | 77.64 (73.92 – 81.35) | N/A | |