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. Author manuscript; available in PMC: 2018 Feb 1.
Published in final edited form as: J Acquir Immune Defic Syndr. 2017 Feb 1;74(2):213–220. doi: 10.1097/QAI.0000000000001181

Table 2.

Association of monocyte cytokine responses with susceptibility to TB recurrence. Cytokine expression in monocytes from the cases, prior to TB acquisition and controls over time were analyzed using the Generalized Estimating Equations (GEE) model correcting for repeated measures and matched variables.

Cytokine No TB recurrence TB recurrence Unadjusted Odds Ratio (95%CI) p-value
N Median (IQR) N Median (IQR)
Monocytes (CD14)
Antigen: BCG
IL-1β 37 0.96 (0.00 – 2.86) 12 1.46 (0.20 – 7.51) 1.30 (1.09 – 1.55) 0.0033
IL-12 36 0.01 (0.00 – 0.51) 9 0.08 (0.00 – 0.34) 0.40 (0.01 – 11.15) 0.5901
IP10 36 0.13 (0.00 – 1.14) 9 0.00 (0.00 – 1.34) 1.53 (0.84 – 2.77) 0.1640
TNF-α 36 1.19 (0.00 – 3.78) 9 1.43 (0.38 – 5.41) 1.06 (0.78 – 1.44) 0.7162
Antigen: LPS
IL-1β 34 21.03 (0.00 – 45.51) 11 0.92 (0.00 – 9.28) 0.94 (0.89 – 1.00) 0.0462
IL-12 33 1.85 (0.00 – 7.28) 9 3.08 (1.31 – 7.69) 0.98 (0.85 – 1.13) 0.8143
IP10 33 0.00 (0.00 – 1.15) 9 0.18 (0.00 – 2.86) 0.94 (0.84 – 1.05) 0.2807
TNF-α 33 57.44 (23.10 – 73.02) 9 41.80 (20.95 – 61.51) 0.95 (0.91 – 1.00) 0.0316
Antigen: HKLM
IL-1β 38 45.45 (23.93 – 70.23) 11 25.11 (4.44 – 52.85) 0.96 (0.92 – 1.00) 0.0564
IL-12 37 4.81 (0.00 – 8.60) 9 7.14 (4.51 – 7.75) 1.07 (0.96 – 1.18) 0.2294
IP10 37 0.52 (0.00 – 1.92) 9 2.13 (0.44 – 2.70) 0.95 (0.86 – 1.04) 0.2768
TNF-α 37 62.30 (28.50 – 74.55) 9 59.60 (43.94 – 71.30) 1.00 (0.95 – 1.05) 0.9469
Antigen: CL075
IL-1β 36 51.16 (32.04 – 73.55) 11 10.05 (1.25 – 62.00) 0.95 (0.91 – 0.99) 0.0243
IL-12 35 6.42 (2.02 – 15.30) 9 11.29 (9.76 – 18.65) 1.02 (0.96 – 1.08) 0.5811
IP10 35 0.09 (0.00 – 1.88) 9 0.54 (0.00 – 1.54) 1.61 (0.80 – 3.24) 0.1815
TNF-α 35 62.88 (46.20 – 76.72) 9 62.71 (24.45 – 77.10) 0.99 (0.94 – 1.03) 0.4948
Antigen: LAMMS
IL-1β 16 34.81 (28.60 – 56.89) 5 12.50 (0.00 – 17.21) N/A
IL-12 15 1.19 (0.33 – 1.42) 2 1.40 (0.95 – 1.85) N/A
IP10 15 0.00 (0.00 – 0.75) 2 0.08 (0.00 – 0.16) N/A
TNF-α 15 40.83 (28.90 – 52.18) 2 43.49 (34.22 – 52.75) N/A
Antigen: TDB
IL-1β 12 19.05 (8.97 – 33.42) 5 0.00 (0.00 – 6.33) N/A
IL-12 11 4.61 (1.96 – 8.65) 2 11.04 (9.17 – 12.90) N/A
IP10 11 0.00 (0.00 – 0.83) 2 0.21 (0.00 – 0.42) N/A
TNF-α 11 71.22 (52.90 – 76.01) 2 77.64 (73.92 – 81.35) N/A