Table 2.

COX inhibition data of 2,3-diaryl-3H-imidazo[4,5-b]pyridine derivatives.

Compd.	IC50 (µmol/L)		Selectivity ratio
	COX-1	COX-2	COX-2/COX-1
3a	10.0±0.01	35.9±2.0	3.59
3b	15.0±0.13	NA	NA
3c	36.0±1.4	15.1±0.9	0.42
3d	42.7±2.5	25.6±1.0	0.60
3e	16.8±0.1	279.3±7.2	16.58
3f	21.8±1.1	9.2±0.02	0.42
3g	19.1±0.3	22.4±2.5	1.17
3h	18.5±0.00	15.4±3.1	0.83
Indomethacin	0.0067±0.00	0.048±0.00	7.16
Celecoxib	15±0.6	0.042±0.00	0.0028

NA: not achieved at the tested concentrations.