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MTX-PG concentrations and hepatotoxicity. (A) Maximum MTX-PG concentrations among groups with or without hepatotoxicity; (B) cut-off values of total MTX-PG concentration for AST/ALT ≥50 and (C) cut-off values of total MTX-PG concentration for AST/ALT ≥100. *p<0.05. ALT, alanine transaminase; AST, aspartate transaminase; AUC, area under the curve; DAS28, Disease Activity Score for 28 joints; MTX-PG, methotrexate polyglutamate.
