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. 2017 Jan 12;19(2):100–111. doi: 10.1016/j.neo.2016.12.009

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© 2016 The Authors

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

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Fig. 2 — Global and local methylation changes in UCS samples. (A) Density plot of global DNA methylation level distribution estimated by methylCRF: normal endometrium (red line), UCS carcinoma components (green line), and UCS sarcoma components (blue line). (B) A total of 7235 DMRs were identified in at least 2 UCS carcinoma components; 4165 DMRs were identified in at least 2 UCS sarcoma components. A total of 3029 UCS common DMRs were recurrent in at least 2 UCS carcinoma components and 2 UCS sarcoma components. (C) Proportion of UCS common DMRs that were hypermethylated (dark orange) and hypomethylated (light orange). (D) Validation of UCS common DMRs using all probes located in DMRs in TCGA Infinium 450K data.