Fig. 3.

Genomic annotation of UCS common DMRs and examples of methylation-silenced TSGs. (A) Heatmap of DMR enrichment for different genomic regions. Promoter_Ref and Promoter_Linc mean 1-kb core promoter of RefSeq genes and lincRNA, respectively. (B) Epigenome Browser views of three TSG promoters with hypermethylated changes across uterine cancers: MeDIP tracks of normal endometrium (10 pooled healthy donors), 3 EACs, 3 UPSCs, 3 UCS carcinoma components, 3 UCS sarcoma components, and 3 ESSs are displayed. (C and D) Methylation levels and gene expression analysis of the same three TSG with hypermethylated promoters in normal endometrium, EAC, UPSC, and UCS samples using TCGA Infinium 450K methylation data and RNA sequencing data.