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. 2017 Jan 16;5(1):1–8. doi: 10.12998/wjcc.v5.i1.1

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©The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved.

This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial.

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Images of E-cadherin expression in cancer cells. A: Low-magnification image of an E-cadherin-immunostained TMA core; B: Low-magnification image of E-cadherin-immunostained TMA core analyzed by Tissue Studio; C: High-magnification (× 400) image of an E-cadherin-immunostained TMA core; D: High-magnification (× 400) image of an E-cadherin-immunostained TMA core analyzed by Tissue Studio. The membranous expression of E-cadherin was assigned to three categories of the degree of expression: High (brown), medium (orange) and low (yellow). The histological score was calculated by the following formula: 1 × %Low + 2 × %Medium + 3 × %High. TMA: Tissue microarray.