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. 2017 Jan 16;7:40468. doi: 10.1038/srep40468

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Copyright © 2017, The Author(s)

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(a) The mRNA level of KLF4 was elevated by miRNA-145 inhibitors. (b) The protein level of KLF4 was up-regulated by miRNA-145 inhibitors. (c) miRNA-145 mimics descreased KLF4 mRNA level. (d) miRNA-145 mimics reduced KLF4 protein level. (e) LX2 cells were co-transfected with negative control with 3′UTR of KLF, miR-145 mimics with 3′UTR of KLF4 or miR-145 with pmirGLO Vector respectively. The dual luciferase activity were detected after 48 hours. All experiments were repeated thrice with triplicate samples in each experiment. The relative value of target mRNA/protein to β-actin was set as 1 in the control. Data are presented by mean ± standard deviation. *p < 0.05; **p < 0.01.