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. 2017 Jan 16;7:40655. doi: 10.1038/srep40655

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Copyright © 2017, The Author(s)

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(A) Enrichment of various histone modifications at P. falciparum genes (gene bodies plus 1 kb upstream of the ATG) in the oocyst displaying significant enrichment in H3K9me3 and high to medium mRNA levels. Heatmaps are sorted by levels of sense transcripts (log10 of normalized counts) in the oocyst stage. The fold change (log2) values of RNA levels for each gene in the heatmap is also depicted (L2FC < −2 are genes up-regulated in the oocyst, whereas L2FC > 2 corresponds to genes up-regulated in the sporozoite). (B) Enrichment of various histone modifications at genes in the sporozoite displaying significant enrichment peaks and high to medium RNA levels in gene bodies plus 1 kb upstream region. Heatmaps are sorted by RNA levels (sense) in the sporozoite stage. Labels and information are as in panel A above. (C) Ratio of enrichment of active and repressive histone modifications between developmental stages for oocyst (left) or sporozoite (right) genes marked with H3K9me3 and expressed at high or intermediate levels. Values above 1 indicate enrichment in the sporozoite relative to the oocyst, whereas values below 1 indicate enrichment in the oocyst relative to the sporozoite. (D) Density of normalized/input corrected reads for each histone modification at sporozoite or oocyst genes containing H3K9me3. The region plotted comprises gene bodies and 2 kb upstream or downstream of the translation start or termination codons, respectively. (E) Example of the distribution of H3K9ac (green), H3K27ac (blue), H3K4me3 (yellow) and H3K9me3 (red) profiles in the coding and flanking regions of the early transcribed membrane protein 5 (ETRAMP5) gene, which contains high levels of H3K9m3 and is differentially expressed between oocyst and sporozoite stages. Red arrows indicate direction of transcription. The ChIP-seq signal corresponds to the same number of reads between the two parasite stages. The input control is also displayed and all tracks are show at equal scale.