Figure 1.

mTORC1 activation and angiogenesis signaling in renal lesions of Tsc2^+/− mice.

Kidney sections prepared from 13-month-old Tsc2^+/− mice were used for IHC analysis. Kidney sections were stained with antibodies against S6 p-S235/236, HIF1α, and VEGFA. Representative sections were shown demonstrating increased phosphorylation of S6 at S235/236 and increased expression of HIF1α and VEGFA in renal lesions including cysts (C), papillary adenomas (P) and solid tumors (S). Scale bars are 100.1 μm.