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. 2017 Jan 13;19(2):112–120. doi: 10.1016/j.neo.2016.12.008

Figure 2.

Figure 2

MAPK signaling and expression of angiogenesis-contributing receptor kinases in renal lesions of Tsc2+/− mice.

Kidney sections prepared from 13-month-old Tsc2+/− mice were used for IHC analysis. Kidney sections were stained with antibodies against RAF1 p-S259 and Erk1/2 p-T202/Y204, VEGFR1, VEGFR2, PDGFRα, and PDGFRβ. Representative sections were shown demonstrating increased phosphorylation of RAF1 at S259 and Erk1/2 at T202/Y204, increased expression of VEGFR1 and PDGFRα, and diminished expression of VEGFR2 and PDGFRβ in renal lesions. Scale bars are 100.1 μm.