. 2016 Nov 30;8(1):118–123. doi: 10.1021/acsmedchemlett.6b00438

Table 5. Rat PK Profiles of Compounds 26 and 27 in Comparison with Idelalisib.

compd	t_1/2 (h)^a	AUC (ng·h/mL)^a	Cl (mL/min/kg)^a	Vz (L/kg)^a	F (%)^b
Idelalisib	0.8	512	32.8	2.2	68
26	3.1	1729	9.6	2.6	101
27	3.3	2040	8.6	2.4	113

Mean values (n = 2) in Wistar rat after an administration of 1 mg/kg i.v.

Mean values (n = 2) in Wistar rat after an administration of 1 mg/kg p.o.