. 2016 Nov 30;8(1):118–123. doi: 10.1021/acsmedchemlett.6b00438

Table 6. Dog PK Profiles of Compounds 26 and 27 in Comparison with Idelalisib.

compd	t_1/2 (h)^a	AUC (ng·h/mL)^a	Cl (mL/min/kg)^a	Vz (L/kg)^a	F (%)^b
Idelalisib	1.6	924	21.5	2.5
26	10.2	9441	1.4	1.2	98
27	4.2	3937	4.2	1.5

Mean values (n = 2) in Beagle dog after an administration of 1 mg/kg i.v.

Mean values (n = 3) in Beagle dog after an administration of 1 mg/kg p.o.