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. 2017 Jan 16;3:16046. doi: 10.1038/cddiscovery.2016.46

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Copyright © 2017 The Author(s)

This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

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Chemical structures of selected monovalent and bivalent IAP antagonists and their ability to induce the degradation of GFP-cIAP1. (a) Covalent attachment at the P4 position of monovalent IAP antagonists increased their ability to induce degradation of GFP-cIAP1. P1, P2, P3 and P4: amino acid positions. (b) The monovalent IAP antagonist, M4, was ~20-fold more potent than B1 in the GFP-cIAP1 degradation assay. Results are mean±S.E.