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. 2017 Jan 16;7:40789. doi: 10.1038/srep40789

Figure 5. BNP is a PGC-1α-dependent myokine.

Figure 5

(A) Overlapping ChIP-Seq peaks of ERRα (light blue) and PGC-1α (dark blue) are located ~7 kb upstream of the Nppb (BNP) RefSeq transcripts and depicted as read densities. Predicted binding sites for AP-1 and ERRα are represented by red and light green circles, respectively, and their genomic positions are referred to the BNP transcription start site (TSS) (B) Relative expression levels of BNP in response to PGC-1α overexpression and shERRα knock-down, in addition to the inverse agonist XCT-790 were determined by RT-PCR. Values represent the mean of at least 3 independent experiments +SEM. ***P < 0.001.