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FDA approved drugs Saquinavir and Amprenavir for the treatment of HIV infections. (a) The structure of Saquinavir in complex with HIV-1 protease (3OXC) (b) the structure of Amprenavir in complex with HIV-1 protease (3NU3) (c) the molecular structure of Saquinavir and (d) the molecular structure of Amprenavir. Amprenavir and Saquinavir target HIV-1 protease and, in part, have been discovered through structure-based computer aided drug discovery methods.
