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LH surge in GnRH-Itgb1−/−. Profile of LH surge in OVX mice of the two genotypes treated with estrogen and progesterone. Note that while control OVX mice (n = 4) exhibited an LH surge in response to gonadal steroid treatment, GnRH-Itgb1−/− littermates (n = 5) did not, confirming that estrogen-based positive feedback is disrupted. Data are represented as means ± SEM. n, number of animals; *p < 0.0001, unpaired Student's t test.
