Scheme 1.

Schematic representation of the solid phase synthesis of v6‐PEG and v6‐PEG‐C16 (top) as well as nanoparticle preparation and application for targeting CD44v6⁺ cells (bottom). i) Peptide synthesis was conducted on Wang resin using standard Fmoc solid phase peptide synthesis to synthesize NEWQG, ii) Fmoc‐NH‐PEG3000‐COOH was conjugated to the free N‐terminus of the immobilized peptide; iii) After Fmoc‐deprotection, palmitic acid was conjugated to the amino terminus of the PEG using HCTU; iv) v6‐PEG‐C16 was cleaved from the resin using a mixture of TFA:H₂O:TIS; v) MeO‐PEG2000‐COOH was conjugated to v6‐peptide by amide coupling; vi) PEG‐v6 was cleaved from the resin using a mixture of TFA:H₂O:TIS; vii) preparation of v6‐PEG‐QDs and their selective binding to CD44v6⁺ cells. Nanoparticles were prepared by self‐assembling of hydrophobic quantum dots with amphiphilic v6‐PEG‐C16 using the lipid film method.