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. 2017 Jan 12;12:267–273. doi: 10.2147/COPD.S116217

Figure 1.

Figure 1

Relative expression of versican mRNA by cultured lung fibroblasts from patients with COPD (n=6) and without COPD (non-COPD; n=6).

Notes: (A) Untreated confluent cultures from COPD and non-COPD patients sampled on day 9 compared to versican siRNA-treated (COPD-T and non-COPD-T) cultures. Cultures were treated only once on day 8. (B) Untreated and treated COPD and non-COPD cultures treated twice on days 8 and 15 and sampled day 16. (C) Untreated and treated COPD and non-COPD cultures treated three times on days 8, 15 and 22 and sampled day 23. Box plots show median, lower quartile and upper quartile values and ranges. Versican siRNA treatment suppressed versican expression in both COPD and non-COPD cell lines (P<0.01).

Abbreviations: siRNA, small interfering RNA; mRNA, messenger RNA.