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. 2017 Jan 10;12:395–410. doi: 10.2147/IJN.S125359

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© 2017 Slastnikova et al. This work is published and licensed by Dove Medical Press Limited

The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed.

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Cytotoxicity of: ¹¹¹In-NOTA–MNT-FA on FR-positive (A) HeLa and (B) SK-OV-3; (C) ¹¹¹In-NOTA–MNT-EGF on EGFR-positive U87MG.wtEGFR cells; and (D) ¹¹¹In-NOTA–MNT-MSH on MC1R-positive B16-F1 cells, all compared to ¹¹¹In control and also FA-blocked ¹¹¹In-NOTA–MNT-FA for HeLa cells.

Note: The significance of the difference was calculated using Kruskal–Wallis test.

Abbreviations: EGFR, epidermal growth factor receptor; FA, folic acid; FR, folate receptor; MC1R, melanocortin receptor-1; MNT, modular nanotransporter; MSH, α-melanocyte-stimulation hormone.