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. Author manuscript; available in PMC: 2017 Jan 16.
Published in final edited form as: J Non Cryst Solids. 2014 Jul 22;407:494–501. doi: 10.1016/j.jnoncrysol.2014.07.005

Figure 4.

Figure 4

Specific heat CV for ℳ (green) and ℋ (red) domains of the EF-Tu and 1α proteins, respectively, calculated from OPEP-REMD simulations. The presence of multiple peaks in the CV profile is caused by the unfolding events of different secondary structure motifs as well as progressive unpacking. In a simple two-state model, the CV is expected to show a single peak at the melting temperature Tm where the populations of the folded (pf) and unfolded (pu) states are equal.

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