Table 1.
Demographic characteristics, GNP, and WIV performance for AD, MCI, and healthy participants
| Mean (SD) | Healthy (n = 229) | MCI (n = 397) | AD (n = 193) |
|---|---|---|---|
| Age | 75.93 (5.03) | 74.80 (7.44) | 75.36 (7.47) |
| Education | 16.04 (2.87) | 15.67 (3.04) | 14.07 (3.13) |
| Sex (% Female) | 48% | 36% | 47% |
| MMSE baseline | 29.11 (1.00)*# | 27.03 (1.79)# | 23.34 (2.06) |
| MMSE 12 months | 29.13 (1.17)*# | 26.40 (2.87)# | 21.13 (4.46) |
| CDR baseline | 0 (0)*# | 0.50 (0.03)# | 0.74 (0.25) |
| CDR 12 months | 0.04 (0.14)*# | 0.53 (0.18)# | 0.99 (0.50) |
| Number of Neuropsychological Tasks completed baseline | 11.74 (0.49) | 11.97 (0.20) | 11.90 (0.38) |
| Number of individuals at follow-up with sufficient data | 208 | 327 | 144 |
| GNP baseline | 0.00 (0.50)*# | −1.35 (0.80)# | −2.42 (0.92) |
| GNP 12 months | 0.00 (0.53)*# | −1.42 (1.01)# | −2.79 (1.4) |
| WIV baseline | 0.87 (0.23)*# | 1.45 (0.48)# | 1.89 (0.62) |
| WIV 12 months | 0.81 (0.24)*# | 1.53 (0.57)# | 2.08 (0.65) |
*
p < 0.001 as compared to MCI;
#
p < 0.001 as compared to AD.
AD, Alzheimer’s disease; CDR, Clinical Dementia Rating; GNP, global neuropsychological performance; MCI, mild cognitive impairment; MMSE; Mini-Mental State Examination; WIV, within-individual variability.