Table 1.
Selected Studies on NSAIDs in Mouse Models of AD
| ref | Year | Model | drug used | age start (months) |
treat time | age end (months) |
Aβ effect | inflamm. Markers |
neuronal or behavioral effect |
|---|---|---|---|---|---|---|---|---|---|
| 55 | 2000 | Tg2576 | ibuprofen | 10 | 6 months | 16 | decreased | decreased | fewer dystrophic neurites |
| 88 | 2001 | Tg2576 | ibuprofen | 10 | 6 months | 16 | rescued open field; lowered caspase activation | ||
| 14 | 17 months | 17 | decreased | decreased | |||||
| 53 | 2001 | Tg2576 | ibuprofen | 3 | 3 days | 3 | decreased | ||
| naproxen | 3 | 3 days | 3 | decreased | |||||
| 89 | 2002 | TG2576 × PS1M146L |
ibuprofen | 7 | 5 months | 12 | decreased | no change | |
| NCX-2216 | 7 | 5 months | 12 | decreased | increased | ||||
| 90 | 2003 | Tg2576 | 13 different NSAIDs |
3 | 3 days | 3 | decreased | ||
| 91 | 2003 | Tg2576 | indomethacin | 12 | 8 months | 20 | decreased | no change | |
| 57 | 2003 | Tg2576 | ibuprofen | 11 | 4 months | 15 | decreased | decreased | |
| pioglitazone | 11 | 4 months | 15 | decreased | no change | ||||
| 92 | 2004 | Tg2576 | indomethacin | 8 | 7 months | 15 | decreased | decreased | |
| 54 | 2005 | APPV717I | ibuprofen | 10 | 7 days | 10 | decreased | decreased | |
| pioglitazone | 10 | 7 days | 10 | decreased | decreased | ||||
| 93 | 2005 | Tg2576 | flurbiprofen | 3–4 | 3 days | 3–4 | decreased | ||
| 94 | 2005 | APP-PS1 | flurbiprofen | 8 | 6 months | 14 | no change | no change | |
| NO-flurbiprofen | 8 | 6 months | 14 | decreased | decreased | ||||
| 95 | 2007 | Tg2576 | flurbiprofen | 8 or 17 | 6 months or 2 weeks |
14 or 19 | no change | rescued Morris water maze | |
| 60 | 2008 | Tg2576 | ibuprofen | 12 | 1 month | 13 | no change | decreased | rescued Morris water maze |
| ibuprofen | 5 | 5 months | 10 | decreased | rescued Morris water maze | ||||
| MF tricyclic | 12 | 1 month | 13 | no change | decreased | rescued Morris water maze | |||
| naproxen | 12 | 1 month | 13 | no change | decreased | rescued Morris water maze | |||
| 96 | 2008 | 3xTg-AD | ibuprofen | 1 | 5 months | 6 | decreased | rescued Morris water maze | |
| 61 | 2009 | R1.40 | ibuprofen | 3 | 3 months | 6 | no change | decreased | lowered markers of neuronal cell-cycle entry |
| naproxen | 3 | 3 months | 6 | no change | decreased | lowered markers of neuronal cell-cycle entry | |||
| 56 | 2012 | R1.40 | ibuprofen | 15 | 9 months | 24 | decreased | decreased | |
| 59 | 2012 | 5x-FAD | ibuprofen | 3 | 3 months | 6 | no change | decreased | worsened cross maze |
| 97 | 2013 | 3xTg-AD | flurbiprofen | 5 | 2 months | 7 | no change | rescued radial arm water maze | |
| 98 | 2013 | 3xTg-AD | SC-560 | 20 | 8 days | 20 | decreased | decreased | rescued Morris water maze |
| 99 | 2013 | R1.40 | tolfenamic acid | 14–20 | 1 month | 15–21 | decreased | rescued Morris water maze and Y Maze | |
| 100 | 2014 | 3xTg-AD | ibuprofen | 1 | 15–22 months |
16–23 | decreased | rescued hippocampal volume by MRI |