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. 2016 Jul 24;7(32):50927–50936. doi: 10.18632/oncotarget.10815

Figure 3. Epsin2 knockdown results in spindle defects and chromosome misalignment in oocyte meiosis.

Figure 3

A. Control and Epsin2-KD oocytes were stained with α-tubulin to visualize spindle (green) and counterstained with propidium iodide to visualize chromosomes (red): (a) A barrel-shape spindle and well-aligned chromosomes can be readily observed in control oocytes; (b-d) Chromosome congression failure indicated by arrowheads and disorganized spindles were frequenly detected in Epsin2-KD oocytes. B. Quantification of control (n = 182) and Epsin2-KD oocytes (n = 167) with spindle defects or chromosome misalignment. Data are expressed as mean percentage ± SD. *p < 0.05 vs. controls. Scale bar, 20μm.