Table 5. Univariate and multivariate analyses of the patients' clinicopathologic factors by Cox regression model.

Factors	Univariate analysis		Multivariate analysis
	HR (95% CI)	P value	HR (95% CI)	P value
Gender	0.825 (0.691–0.984)	0.033	0.808 (0.732–1.091)	0.301
Age	0.744 (0.637–0.869)	< 0.001	0.751 (0.611–0.881)	< 0.001
Tumor location	0.933 (0.852–1.022)	0.138	–	–
Macroscopic type	1.329 (1.137–1.553)	< 0.001	1.016 (0.872–1.221)	0.754
Tumor differentiation	1.109 (1.032–1.257)	0.041	1.012 (0.819–1.273)	0.288
Lymphovascular invasion	1.246 (1.129–1.478)	< 0.001	1.138 (0.932–1.431)	0.064
Perineural invasion	1.051 (1.002–1.171)	0.087	–	–
Adjuvant chemotherapy	1.244 (1.112–1.653)	0.032	1.104 (0.912–1.412)	0.136
Tumor size	1.682 (1.461–1.796)	< 0.001	1.181 (1.041–1.353)	0.006
Retrieved lymph node	0.893 (0.652–1.012)	0.211	–	–
T stage	1.539 (1.404–1.686)	< 0.001	1.271 (1.151–1.423)	< 0.001
N stage	1.593 (1.473–1.723)	< 0.001	1.209 (1.013–1.389)	0.003
Nr stage	1.856 (1.674–2.056)	< 0.001	1.413 (1.147–1.698)	< 0.001

HR: Hazard Ratio; CI: Confidence Interval; – :not enter the regression model.