Table 1. Characteristics of the 26 articles included in the meta-analysis.
| Study | Country | Ethnicity | Source | Polymorphism | Sample size | HWE | HWE | Score |
|---|---|---|---|---|---|---|---|---|
| of control | type | (case/control) | (cases) | (control) | ||||
| Hayashi,1992 | Japan | Asian | PB | rs1048943 | 85/358 | 0.114 | 0.332 | 12 |
| Sivaraman,1994 | Mixed | Caucasian | PB | rs1048943 | 43/47 | 0.227 | 0.230 | 11 |
| rs4646903 | 43/47 | 0.001 | 0.245 | 11 | ||||
| Frische,1999 | Germany | Caucasian | PB | rs1048943 | 187/101 | 0.622 | 0.839 | 13 |
| rs4646903 | 187/101 | 0.496 | 0.563 | 13 | ||||
| Ishibe,2000 | America | Caucasian | PB | rs1048943 | 212/221 | 0.018 | 0.057 | 13 |
| rs4646903 | 212/221 | 0.247 | 0.428 | 13 | ||||
| Sachse,2002 | Britain | Caucasian | PB | rs1048943 | 490/592 | 0.035 | 0.002 | 11 |
| rs4646903 | 490/592 | 0.040 | 0.596 | 14 | ||||
| Ye,2002 | Britain | Caucasian | PB | rs4646903 | 41/82 | 0.613 | 0.599 | 11 |
| Slattery,2004 | America | Caucasian | PB | rs1048943 | 1791/2180 | 0.000 | 0.000 | 12 |
| rs4646903 | 1805/2164 | 0.080 | 0.118 | 15 | ||||
| Hou,2005 | Mixed | Mixed | HB | rs1048943 | 675/679 | 0.117 | 0.478 | 12 |
| Landi,2005 | Spain | Caucasian | HB | rs1048943 | 362/323 | 0.617 | 0.469 | 11 |
| rs4646903 | 358/305 | 0.717 | 0.793 | 11 | ||||
| Chen,2005 | China | Asian | PB | rs4646903 | 139/340 | 0.978 | 0.821 | 13 |
| Little,2006 | Britain | Caucasian | PB | rs1048943 | 251/396 | 0.602 | 0.534 | 14 |
| rs4646903 | 232/378 | 0.206 | 0.448 | 14 | ||||
| Bente,2006 | Australia+ Poland | Caucasian | HB | rs4646903 | 118/100 | 0.039 | 0.637 | 10 |
| Youshida,2007 | Japan | Asian | PB | rs1048943 | 66/121 | 0.910 | 0.800 | 11 |
| rs4646903 | 66/121 | 0.244 | 0.623 | 11 | ||||
| Yeh,2007 | Taiwan, China | Asian | HB | rs1048943 | 717/729 | 0.000 | 0.280 | 12 |
| Kiss,2007 | Hungary | Caucasian | HB | rs1048943 | 500/500 | 0.172 | 0.315 | 12 |
| Pereira, 2008 | Brazil | Caucasian | PB | rs1048943 | 114/114 | 0.000 | 0.071 | 12 |
| Pande,2008 | America | Caucasian | PB | rs1048943 | 120/137 | 0.294 | 0.000 | 10 |
| rs4646903 | 120/137 | 0.046 | 0.272 | 13 | ||||
| Zheng,2009 | China | Asian | PB | rs1048943 | 79/110 | 0.056 | 0.031 | 8 |
| rs4646903 | 79/110 | 0.479 | 0.272 | 11 | ||||
| Liu,2009 | China | Asian | HB | rs4646903 | 75/100 | 0.000 | 0.000 | 6 |
| Kobayashi,2009 | Japan | Asian | HB | rs1048943 | 117/289 | 0.164 | 0.000 | 7 |
| Nisa,2010 | Japan | Asian | PB | rs1048943 | 685/778 | 0.580 | 0.970 | 14 |
| rs4646903 | 685/778 | 0.423 | 0.718 | 14 | ||||
| Cleary,2010 | Canada | Caucasian | PB | rs1048943 | 1174/1293 | 0.000 | 0.006 | 11 |
| rs4646903 | 1174/1293 | 0.281 | 0.062 | 14 | ||||
| Houlle,2011 | France | Caucasian | HB | rs1048943 | 329/419 | 0.651 | 0.546 | 11 |
| rs4646903 | 329/419 | 0.804 | 0.362 | 11 | ||||
| Darazy,2011 | Lebanon | Asian | PB | rs4646903 | 70/70 | 0.000 | 0.000 | 5 |
| Saeed,2013 | Saudi Arabia | Asian | HB | rs4646903 | 100/79 | 0.374 | 0.726 | 10 |
| Gil,2014 | Poland | Caucasian | HB | rs1048943 | 478/404 | 0.574 | 0.095 | 11 |
PB, population-based; HB, hospital-based; HWE, Hardy-Weinberg equilibrium.