. 2016 Jun 30;7(32):51365–51374. doi: 10.18632/oncotarget.10331

Table 2. Meta-analysis of the association between CYP1A1 polymorphisms and CRC risk.

	G vs. A			GG vs. AA			GA vs. AA			GA/GG vs. AA			GG vs. GA/AA
Variables	OR(95%CI)	P_OR^a	P_het^b	OR (95% CI)	P_OR^a	P_het^b	OR (95% CI)	P_OR^a	P_het^b	OR (95% CI)	P_OR^a	P_het^b	OR (95% CI)	P_OR^a	P_het^b
rs1048943	1.28 (1.08–1.52)	0.004	0.000	1.54 (1.25–1.91)	0.000	0.228	1.26 (1.00–1.60)	0.05	0.000	1.31 (1.05–1.64)	0.018	0.000	1.56 (1.26–1.91)	0.000	0.664
Ethnicity
Asian	1.14 (0.87–1.50)	0.346	0.000	1.61 (1.04–2.47)	0.031	0.049	0.93 (0.67–1.29)	0.661	0.001	1.04 (0.75–1.48)	0.809	0.000	1.59 (1.25–2.02)	0.000	0.184
Caucasian	1.33 (1.06–1.68)	0.015	0.000	1.48 (0.95–2.32)	0.083	0.526	1.42 (1.04–1.96)	0.030	0.000	1.43 (1.05–1.95)	0.022	0.000	1.41 (0.92–2.17)	0.113	0.849
Source of control
PB	1.40 (1.09–1.80)	0.009	0.000	1.61 (1.03–2.53)	0.038	0.054	1.48 (1.06–2.06)	0.021	0.000	1.52 (1.10–2.11)	0.011	0.000	1.37 (1.04–1.81)	0.024	0.373
HB	1.13 (0.91–1.40)	0.255	0.026	1.68 (1.22–2.33)	0.002	0.935	0.99 (0.72–1.38)	0.972	0.000	1.05 (0.79–1.41)	0.727	0.001	1.82 (1.33–2.50)	0.000	0.985
Score
High	1.28 (1.08–1.52)	0.004	0.000	1.48 (1.18–1.86)	0.001	0.591	1.28 (1.01–1.62)	0.043	0.000	1.32 (1.05–1.65)	0.017	0.000	1.49 (1.19–1.86)	0.001	0.869
Low	1.32 (0.56–3.11)	0.530	0.000	1.57 (0.42–5.93)	0.507	0.030	1.24 (0.36–4.24)	0.735	0.000	1.31 (0.41–4.22)	0.652	0.000	2.02 (1.19–3.44)	0.009	0.141
HWE
Yes	1.30 (1.05–1.61)	0.015	0.000	1.51 (1.17–1.94)	0.001	0.382	1.31 (0.96–1.77)	0.088	0.000	1.35 (1.01–1.81)	0.041	0.000	1.52 (1.19–1.95)	0.001	0.719
No	1.25 (0.91–1.73)	0.173	0.000	1.63 (1.11–2.41)	0.013	0.113	1.19 (0.79–1.79)	0.417	0.000	1.23 (0.83–1.83)	0.297	0.000	1.63 (1.12–2.39)	0.011	0.322
	C vs. T			CC vs. TT			CT vs. TT			CT/CC vs. TT			CC vs. CT/TT
rs4646903	1.09 (0.96–1.23)	0.186	0.001	1.11 (0.81–1.53)	0.507	0.032	1.04 (0.91–1.18)	0.594	0.034	1.07 (0.93–1.22)	0.342	0.009	1.10 (0.82–1.47)	0.530	0.053
Ethnicity
Asian	1.27 (0.92–1.75)	0.140	0.000	1.17 (0.75–1.82)	0.502	0.077	1.23 (0.85–1.77)	0.267	0.016	1.32 (0.89–1.96)	0.168	0.001	1.05 (0.84–1.32)	0.666	0.279
Caucasian	1.09 (0.92–1.28)	0.331	0.075	1.23 (0.89–1.72)	0.213	0.136	0.98 (0.88–1.10)	0.710	0.114	1.00 (0.90–1.12)	0.943	0.150	1.52 (0.81–2.85)	0.192	0.085
Source of control
PB	0.99 (0.92–1.06)	0.774	0.193	1.04 (0.75–1.45)	0.826	0.058	0.98 (0.90–1.08)	0.726	0.175	0.99 (0.91–1.07)	0.745	0.235	1.05 (0.76–1.44)	0.783	0.064
HB	1.55 (0.92–2.61)	0.100	0.000	1.61 (0.92–2.82)	0.096	0.141	1.36 (0.86–2.14)	0.190	0.017	1.51 (0.90–2.54)	0.122	0.001	1.51 (0.87–2.62)	0.144	0.206
Score
High	1.05 (0.93–1.18)	0.465	0.005	1.02 (0.74–1.41)	0.886	0.052	1.02 (0.90–1.17)	0.741	0.029	1.04 (0.91–1.18)	0.604	0.016	1.03 (0.76–1.40)	0.859	0.064
Low	1.85 (1.19–2.87)	0.006	0.644	2.24 (1.04–4.80)	0.039	0.905	1.62 (0.80–3.28)	0.180	0.696	1.88 (1.06–3.35)	0.031	0.709	1.99 (0.95–4.16)	0.068	0.846
HWE
Yes	1.05 (0.93–1.18)	0.465	0.005	1.02 (0.74–1.41)	0.886	0.052	1.02 (0.90–1.17)	0.741	0.029	1.04 (0.91–1.18)	0.604	0.016	1.03 (0.76–1.40)	0.859	0.064
No	1.85 (1.19–2.87)	0.006	0.644	2.24 (1.04–4.80)	0.039	0.905	1.62 (0.80–3.28)	0.180	0.696	1.88 (1.06–3.35)	0.031	0.709	1.99 (0.95–4.16)	0.068	0.846

P value of the Z-test for odds ratio test;

P value of the Q-test for heterogeneity test; PB, population based; HB, hospital based; HWE, Hardy-Weinberg equilibrium.