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. 2016 Jun 9;7(32):51553–51568. doi: 10.18632/oncotarget.9928

Figure 5. Alterations in membrane organization lead to transcriptional reprogramming of the cell.

Figure 5

A. Gene sets for pathways associated with an EMT state are scored (y-axis) across samples with and without EMT inducers (Snail, top; TGF-β, bottom), and with and without DHA treatment (x-axis). Scores are relative, and higher scores indicate stronger evidence for activation of the pathway. B. This network shows the relationship between the pathways (shown as nodes) associated with stable (red nodes) or destabilized (blue) raft domains. The labels summarize the pathways that comprise dense hubs within the network. C. Relative gene expression (y-axis) of inducers of EMT SNAI1 and ZEB1 after treatment with 2.5 nM TGF-β and 20 μM DHA. D. Immunoblots show the expression of cell signaling proteins after treatment with TGF-β and DHA.