Table 1. Label incorporation from glucose into the fatty acids palmitate and stearate.
| Incorporation of glucose label into (ratio): | THP-1 cells | HCT116 cells | ||
|---|---|---|---|---|
| WT | KD | WT | KD | |
| palmitate versus nucleotides | 0.89 ± 0.01 | 0.82 ± 0.01*** | 0.17 ± 0.04 | 0.06 ± 0.02** |
| stearate versus nucleotides | 0.40 ± 0.03 | 0.33 ± 0.02* | 0.032 ± 0.004 | 0.017 ± 0.003** |
Label incorporation of glucose in palmitate and stearate was compared to label incorporation in nucleotides in THP-1 and HCT116 cell (WT or silenced for TKTL1) (mean±SD; n=4; p-values are adjusted using a Holm method, *p<0.05, **p<0.01, ***p<0.005). The values represent the ratio of the incorporation of glucose label into palmitate/stearate versus incorporation of glucose label into nucleotides.