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. 2016 Jun 21;7(32):51955–51964. doi: 10.18632/oncotarget.10192

Figure 5. Upregulation of ST6Gal-I protects Huh7 cells from docetaxel-induced apoptosis through inhibition of p38 MAPK mediated mitochondrial-dependent pathway.

Figure 5

Par. EV and ST1/2 cells were treated with the presence or absence of 10μM docetaxel for 24h. A. ST6Gal-I, cytochrome c, cleaved forms of caspase-9, 3 and PARP protein levels were determined by western blot. C. Bcl-2 family, p38 and pp38 protein levels were determined by western blot. B and D. Quantification of protein levels was performed by densitometry. Results represent the mean +/− SD of the expression levels from three independent experiments standardized to GAPDH expression and normalized to 100% in Par. cells without docetaxel treatment. (*P<0.05 compared to Par. cells without docetaxel, #P<0.05 compared to Par. cells with docetaxel).