Table 2. Features of patients with CNS disease.

Patient	CNS Symptoms	CSF Flow cytometry / Cytology	Imaging at time of CNS disease
1	None	Paucicellular cytospin specimen with rare atypical lymphocytes	CT head - Negative
2	None	CD4+, CD25+, CD7-, CD26-	CT head - Negative
3	Cranial nerve palsy	CD3 +, CD4+, CD25+, CD27+, CD7-, CD26-	MRI Brain - Diffuse dural thickening
4	None	CD2+, CD3+, CD4+, CD5+, CD7-	CT head - Negative
5	None	23% CD4+ T-cells with reduced CD7 expression, partial expression of CD25	CT head-Negative
6	None	Positive for malignant cells,	MRI head-Meningeal enhancement
7	None	Abnormal CD4+ T-cells that lack CD7	CT Head - Negative
8	Headache	Positive for malignant cells	CT head-Right frontal skull lesion with dehiscence of the inner table, with a minimal epidural component
9	None	CD2+, CD3+, CD4+, CD5+, CD8+, CD7-	MRI Brain - Normal
10	None	CD4+, CD25+, CD7- phenotype	MRI Brain - Faint thin dural enhancement
11	None	CD4+, CD25+ T-cells	CT head - Negative
12	Headache	0.6% CD3+, CD4+, CD7-, CD25+ T-cells	MRI Brain - Large destructive sinonasal mass, extension to adjacent structures. Parameningeal extension.
13	None	CD2+, CD7+, CD3+, CD5+, CD4-, CD8-	CT head - Negative
14	None	9% T-cells CD4+, CD7-, mostly CD25+	CT head - Negative
15	None	Atypical. Scattered lymphocytes, some with mild atypia.	CT head - Negative

CNS: central nervous system; CSF: cerebral spinal fluid; CT: computed tomography; MRI: magnetic resonance imaging.

(n=15).