Table 2. tOPN protein expression evaluated by IHC and correlation with clinicopathological associations in formalin-fixed paraffin-embedded (FFPE).

Tissue	Clinicopathological features (N)	tOPN tissue expression (Average ± SD)	p-value
cPTC	Stroma
	Absent (n=17)	1.53 ± 2.18	p=0.01
	Hyaline (n=19)	3.37 ± 2.16
	Vascular Invasion
	Absent (n=16)	1.44 ± 2.15	p=0.05
	Present (n=23)	2.91 ± 2.41
	Extrathyroid Extension
	Absent (n=21)	0.67 ± 1.98	p=0.07
	Present (n=18)	3.00 ± 2.56