Table 1. Effect of treatment with GHRH antagonists JMR-132 (10 μg/day) and JV-1-38 (20 μg/day) on tumor weight and on tumor burden in PC3 cells xenografted into nude mice.
Treatment groups and the number of evaluable animals | Tumor weight, mg (% inhibition) | Tumor burden, μg/g body weight (% inhibition) |
---|---|---|
Control (n = 10) | 756 ± 101 | 24.59 ± 3.26 |
JMR-132 (n = 6) | 235 ± 140 (68)* | 10.15 ± 4.08 (58)* |
JV-1-38 (n = 6) | 270 ± 102 (64)* | 8.40 ± 3.08 (66)* |
Values are mean ± SE.
P < 0.05 vs. Control.