Figure 2. Implication of endocannabinoid pathway in endometrioid endometrial carcinoma (EEC) progression.

Levels of cannabinoid related metabolites, the stearamide A. and the monoolein B. are increased in EEC samples. C. Predictive power of stearamide in EEC determination. * P<0.05 D. The levels of cannabinoid receptor 1 (CR1) are increased in ECC tissue samples whereas there are not differences in CR2 levels E. Increased levels of CR1 F. and CR2 G. in stages III-IV of EEC. H. PLS-DA graphs demonstrating different metabolomic profiles in EEC, grades 1-2 and 3. Blue spots represents normal endometrium samples (NE), red spots endometrioid endometrial carcinoma grades 1 and 2 and green spots from endometrioid endometrial carcinoma grade 3. * P<0.05