Table 5. Difference of characteristics among co-existing BC and TC.
| Characteristics | Co-existing BC and TC (n=261) | P value | ||
|---|---|---|---|---|
| B-T n=91 (34.9%) |
T-B n=117 (44.8%) |
B=T n=53 (20.3%) |
||
| Age at first primary cancer (year, mean ± SD) | 47.88±9.55* | 46.38±9.66 | 43.66±10.03* | 0.044 |
| Duration before second primary cancer (years, mean± SD) | 4.09±3.13 | 5.82±3.04 | — | <0.001 |
| BC characteristics | ||||
| ER+, n(%) | 70(76.9) | 95(81.2) | 40(75.5) | 0.629 |
| PR+, n (%) | 68(74.7) | 93(79.5) | 38(71.7) | 0.497 |
| HER2 (%) | 25(27.5) | 31(26.5) | 19(35.8) | 0.434 |
| Ki-67 | 30(5~50) | 30(5~50) | 25(5~45) | 0.234 |
| P53 | 10(0~35) | 15(0~40) | 10(0~35) | 0.901 |
| TC characteristics | ||||
| FT3 (pmol/L, median InterQuartile Range) | 7.13(5.44~9.64) | 7.23(5.24~9.66) | 7.25(5.34~9.56) | 0.643 |
| FT4 (pmol/L, median InterQuartile Range) | 10.10(8.54~12.45) | 10.12(8.21~12.13) | 10.64(8.41~13.03) | 0.223 |
| TSH (mIU/L, median InterQuartile Range) | 2.34(1.33~3.34) | 2.67(1.96~3.42) | 2.87(1.90~3.32) | 0.742 |
| TG (μg/L, median InterQuartile Range) | 60.77(29.78~71.24) | 59.23(29.89~70.25) | 59.44(26.89~70.66) | 0.256 |
| TGAb (IU/ml, median InterQuartile Range) | 5.87 (1.92~8.33) | 5.25 (1.98~8.38) | 5.23 (2.18~8.88) | 0.811 |
| TPOAb (IU/ml, median InterQuartile Range) | 7.33(3.23~10.22) | 7.69(3.52~10.24) | 7.67(3.77~10.74) | 0.245 |
*
analyzed by post-hoc test, p = 0.012.
Abbreviations: BC, breast cancer; TC, thyroid cancer; B-T, BC followed by TC metachronously; B=T, BC and TC occurred synchronously ; T-B, TC followed by BC metachronously; Co-existing BC and TC, total cases of B-T group, B=T group and T-B group.