Table 4.
Baseline characteristics of the patients with visceral leishmaniasis who received short course and conventional course of Glucantime in the third phase of the study
| Short-course therapy group (N = 49) | Conventional course therapy group (N = 61) | P value | |
|---|---|---|---|
| Characteristic | |||
| Age (month) | 28.16 ± 26.37 (3–108) | 23.84 ± 24.89 (2–156) | 0.393 |
| Weight (kg) | 10.6 ± 4.1 (6–25) | 10.2 ± 4.4 (4.3–35) | 0.575 |
| Signs and symptoms | |||
| Palpable spleen size (cm below costal margin) | 4.9 ± 2.8 (1–12) | 4.4 ± 2.1 (0–10) | 0.849 |
| Palpable liver size (cm below costal margin) | 3.5 ± 2.1 (0–10) | 3.1 ± 1.7 (0–7) | 0.313 |
| Jaundice (%) | 4.7 | 4.5 | 0.603 |
| Ascites (%) | 0 | 1.5 | 1.000 |
| Petechia/purpura (%) | 2.3 | 0 | 0.445 |
| Fever duration before treatment (day) | 23.4 ± 12.3 (7–60) | 19.6 ± 7.8 (3–40) | 0.390 |
| Laboratory values | |||
| White blood cell count(×103/mm3) | 5,566 ± 2,250 (2,000–11,800) | 5,781 ± 3,064 (600–15,500) | 0.547 |
| Platelet count (×103/mm3) | 128 ± 83 (18–357) | 130 ± 86 (17–510) | 0.662 |
| Hemoglobin (g/dL) | 8.47 ± 2 (3.4–13.4) | 8.21 ± 1.71 (4–14.8) | 0.999 |
| Anemia (%) | 90.4 | 92.4 | 1.000 |
| Serum alanine aminotransferase (U/L) | 151 ± 176 (23–925) | 192 ± 226 (17–1,015) | 0.952 |
| Serum aspartate aminotransferase (U/L) | 74 ± 104 (5–590) | 74 ± 82 (5–462) | 0.381 |
| Total bilirubin (mg/dL) | 0.83 ± 1.5 (0.2–9.6) | 0.72 ± 1.08 (0.2–8.5) | 0.921 |
| Albumin (g/dL) | 3.58 ± 0.64 (2.1–4.9) | 3.59 ± 0.66 (2–5.2) | 0.851 |
| Prothrombin time (second) | 14.32 ± 1.26 (13–17) | 14.46 ± 2.2 (11–20) | 0.409 |
| Partial thromboplastin time (second) | 36.88 ± 13.15 (11–70) | 40.65 ± 13.9 (20–78) | 0.186 |
| Urine protein (dipstick positive plus) | 0.585 | ||
| No (%) | 61.9 | 75 | |
| 1+ (%) | 9.5 | 7.8 | |
| 2+ (%) | 4.8 | 4.7 | |
| 3+ (%) | 23.8 | 12.5 | |
| Pyuria (%) | 38.1 | 42.2 | |
| Hematuria (%) | 9.5 | 14.1 | |
| Urine culture (%) | 17.9 | 19.4 | |
| Disease indices | |||
| Indirect fluorescent antibody titer | 0.716 | ||
| Negative (%) | 10.3 | 6.7 | |
| 1/64 (%) | 17.9 | 13.3 | |
| 1/128 (%) | 33.3 | 33.3 | |
| 1/256 (%) | 12.8 | 26.7 | |
| 1/512 (%) | 17.9 | 11.7 | |
| 1/1,024 (%) | 7.7 | 8.3 | |
| Parasite found in the bone marrow (%) | 25.8 | 34.8 | |
Plus–minus values are mean ± SD. Data shown in parentheses are minimum–maximum. To convert the values for bilirubin to micromoles per liter, multiply by 17.1.