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. Author manuscript; available in PMC: 2018 Feb 1.
Published in final edited form as: Pain. 2017 Feb;158(2):230–239. doi: 10.1097/j.pain.0000000000000742

Figure 1.

Figure 1

rs3750625 is in the seed binding region of miR-34a (A) rs3750625 (black arrow, bolded nucleotides) maps within a potential seed binding site for miR-34a. Predicted base pairing between miR-34a and the ADRA2A 3′UTR with either the major or minor allele is indicated by a solid vertical line (Watson-Crick) or by a gray dot (wobble). The seed region of miR-34a (nucleotides 2-8) is underlined. (B) Nucleotide conservation amongst 7 mammals in the miR-34a binding region of ADRA2A. The arrow indicates the location of rs3750625. Conserved nucleotides are greyed.