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. Author manuscript; available in PMC: 2018 Feb 1.
Published in final edited form as: Pain. 2017 Feb;158(2):230–239. doi: 10.1097/j.pain.0000000000000742

Figure 2.

Figure 2

Acute MSP following trauma is more severe in individuals with the minor allele at ADRA2A rs3750625 who also reported stress in the early aftermath of trauma exposure. (A) Following sexual assault, MSP severity was higher in stressed individuals with at least one copy of the ADRA2A rs3750625 minor allele (CA/AA) versus individuals with the major allele (CC), *p = 0.020. Non-stressed individuals with at least one copy of the ADRA2A rs3750625 minor allele reported lower MSP severity, p = 0.116. A stress cut-off of 77 was used to distinguish stressed from non-stressed individuals (ASD scale, median) (B) A similar crossover interaction was observed following motor vehicle collision. A distress cut off of 23 was used to distinguish distressed from non-distressed individuals (PDI scale, previously validated cut-off[41]).