(A) Cumulative food intake throughout the intervention, (B) averaged food intake, (C) resting energy expenditure (REE), (D) spontaneous physical activity (SPA), and (E) wheel running volume. Values are means ± SE (n=7–8 per group). Line = line main effect, HCR vs. LCR; Treatment = treatment main effect, SED vs. EX; Interaction = line × treatment interaction. * Denotes difference (P<0.05) between SED and EX within line. # P<0.05, significantly different from HCR EX.