(A) skeletal muscle IL-6 mRNA, (B) skeletal muscle IL-10 mRNA, (C) plasma IL-6, (D) plasma IL-10, (E) pAMPK Thr172 (activation site) and (F) pAMPK Ser485/491 (inhibition site). Values are normalized by total AMPK; values are means ± SE (n=6–8 per group). Line = line main effect, HCR vs. LCR; Treatment = treatment main effect, SED vs. EX; Interaction = line × treatment interaction. * Denotes difference (P<0.05) between SED and EX within line.