Table 2.
Cancer diagnosis and treatment changes by decade
| 1970-1979 (N=4618) | 1980-1989 (N=4669) | 1990-1999 (N=5279) | |
|---|---|---|---|
| Parameter | % | %* | %* |
| Leukemia | 32.5 | 36.8 | 41.9 |
| Central Nervous System | 11.5 | 14.2 | 17.8 |
| Hodgkin Lymphoma | 17.8 | 15.6 | 11.3 |
| Non-Hodgkin Lymphoma | 7.5 | 9.8 | 8.3 |
| Wilms Tumor | 8.6 | 4.9 | 6.2 |
| Neuroblastoma | 6.3 | 3.3 | 3.6 |
| Rhabdomyosarcoma | 6.2 | 4.4 | 3.4 |
| Bone tumor | 9.5 | 10.9 | 7.5 |
| Cranial radiation | 37.5 | 29.3 | 20.4 |
| Mean (SD) dose (cGy) | 3053 (1332) | 3083 (1871) | 3310 (2164) |
| Chest radiation | 31.6 | 24.2 | 18.7 |
| Mean (SD) dose (cGy) | 3156 (1087) | 2872 (1216) | 2403 (1150) |
| Abdominal radiation | 31.7 | 19.2 | 15.6 |
| Mean (SD) dose (cGy) | 3017 (988) | 2689 (1185) | 2169 (1194) |
| Pelvic radiation | 25.2 | 15.6 | 13.2 |
| Mean (SD) dose (cGy) | 3057 (1111) | 2838 (1340) | 2297 (1364) |
| Alkylating agent† | 47.9 | 59.6 | 58.1 |
| Mean (SD) (mg/m2) | 10491 (10257) | 8301 (8265) | 8418 (9323) |
| Anthracycline‡ | 31.0 | 55.9 | 66.1 |
| Mean (SD) (mg/m2) | 335 (290) | 248 (163) | 193 (139) |
| High dose methotrexate§ | 5.1 | 13.8 | 21.3 |
| Prednisone | 47.4 | 49.4 | 48.1 |
| Dexamethasone | 3.1 | 13.0 | 25.5 |
| Vincristine | 72.3 | 71.3 | 72.0 |
| Bleomycin | 2.3 | 10.7 | 7.6 |
| Cisplatin | 0.9 | 9.0 | 8.9 |
| Amputation | 35.3 | 26.7 | 12.0 |
| Splenectomy | 74.7 | 57.9 | 9.3 |
| Hematopoietic stem cell transplant | 0.2 | 1.9 | 2.9 |
| Grade 3-4 chronic condition with onset prior to baseline | 33.4 | 25.8 | 21.0 |