Table 1.

The mean and standard deviation of the deformation recovery error (in voxels) when using sinusoidal simulated deformation spatially oriented along the cardinal axes. MI=mutual information, NMI=normalized mutual information, SSD=sum of squared difference, MSE=mean squared error, and CC=cross-correlation.

VABRA	NMI	SSD
T1w→T2w	0.223(0.366)	22.654(32.058)
$[[\mathrm{T}1\mathrm{w},\widehat{\mathrm{T}2}\mathrm{w}]\Rightarrow [\widehat{\mathrm{T}1}\mathrm{w},\mathrm{T}2\mathrm{w}]$	0.210(0.342)	0.150(0.243)
$[\overline{\mathrm{T}1}\mathrm{w},\widehat{\mathrm{T}2}\mathrm{w}]\Rightarrow [\widehat{\mathrm{T}1}\mathrm{w},\overline{\mathrm{T}2}\mathrm{w}]$	0.112(0.187)	0.142(0.248)
[T1w, T2w]⇒[T1w, T2w]	0.222(0.366)	0.124(0.205)

Elastix	MI	MSE
T1w→T2w	0.135(0.229)	15.896(22.551)
$[\mathrm{T}1\mathrm{w},\widehat{\mathrm{T}2}\mathrm{w}]\Rightarrow [\widehat{\mathrm{T}1}\mathrm{w},\mathrm{T}2\mathrm{w}]$	0.132(0.216)	0.185(0.321)
$[\overline{\mathrm{T}1}\mathrm{w},\widehat{\mathrm{T}2}\mathrm{w}]\Rightarrow [\widehat{\mathrm{T}1}\mathrm{w},\overline{\mathrm{T}2}\mathrm{w}]$	0.144(0.244)	0.196(0.333)
[T1w, T2w]⇒[T1w, T2w]	0.105(0.220)	0.122(0.171)

SyN	MI	MSE	CC
T1w→T2w	0.179(0.299)	1.851(2.969)	0.577(0.962)
$[\mathrm{T}1\mathrm{w},\widehat{\mathrm{T}2}\mathrm{w}]\Rightarrow [\widehat{\mathrm{T}1}\mathrm{w},\mathrm{T}2\mathrm{w}]$	0.138(0.232)	0.167(0.277)	0.147(0.246)
$[\overline{\mathrm{T}1}\mathrm{w},\widehat{\mathrm{T}2}\mathrm{w}]\Rightarrow [\widehat{\mathrm{T}1}\mathrm{w},\overline{\mathrm{T}2}\mathrm{w}]$	0.145(0.248)	0.221(0.359)	0.160(0.271)
[T1w, T2w]⇒[T1w, T2w]	0.134(0.229)	0.150(0.256)	0.126(0.215)