Figure 2.

Exocrine pancreas and complement as central players in multiple organ dysfunction. In the context of acute pancreatitis, cross talk between complement, coagulation, and immune cells, such as neutrophil granulocytes and monocytes, drives multiple organ dysfunction. Systemic inflammatory response in turn mediates local organ damage and dysfunction. Abbreviations: ALF, acute liver failure; ARDS, acute respiratory distress syndrome; AKI, acute kidney injury.